1113 Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation
نویسندگان
چکیده
Psoriasis is a refractory and difficult-to-treat skin disorder. Neutrophil-targeting approach represents promising option for psoriasis therapy. This study developed examined NIMP-R14-conjugated immunonanoparticles specific targeting to neutrophils associated with psoriasiform dermatitis. In the process, roflumilast (RFL), as phosphodiesterase (PDE) 4 inhibitor, was encapsulated into nanocarriers assess anti-inflammatory capability against primary neutrophil activation murine lesion. The monovalent antibody-conjugated nanoparticles offered precise uptake by both human mouse neutrophils. intracellular RFL concentration of immunonanocarriers five-fold superior that passive counterparts. specifically recognized through Ly6 antigen no apparent cytotoxicity. mitigated superoxide anion production migration activated Thein vivo biodistribution in mice showed antibody conjugation increased nanoparticle residence systemic circulation after intravenous administration. On other hand, most were accumulated lesional subcutaneous injection. actively-targeted better than free unfunctionalized at suppressing inflammation. reduced recruitment epidermal hyperplasia plaque. Intravenous treatments significantly overexpressed cytokines chemokines inflamed skin, demonstrating nanosystems could systematically locally alleviate results indicated RFL-loaded have potential an anti-autoimmune disease delivery system targeting.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.1125